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. 2003 Dec 15;100(26):15498–15503. doi: 10.1073/pnas.2531778100

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Copyright © 2003, The National Academy of Sciences

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Fig. 5. — Rate constant representations (40) for βCD binding. The representations are not quantitative and are intended to illustrate the two classes of kinetics observed when βCD binds to the αHL pore from the trans side of the bilayer. (A) Rate constant representations for pores exemplified by P_NN-E and P_NN-D. The thick line is at 0 mV. At positive potentials (bottom line), binding is enhanced for these cation-selective pores. The primary effect is on k_on. Binding is diminished at negative potentials (top line). (B) Rate constant representations for pores exemplified by P_NN-R and P_NN-K. The thick line is at 0 mV. At positive potentials (top line), binding is diminished for these anion-selective pores. Both k_on and k_off are affected. Binding is enhanced at negative potentials (bottom line).