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. Author manuscript; available in PMC: 2011 Apr 13.
Published in final edited form as: J Immunol. 2010 Oct 29;185(11):7107–7114. doi: 10.4049/jimmunol.1002756

FIGURE 5.

FIGURE 5

Tissue expression of MAdCAM colocalizes with CD8+ infiltrates in CIN2/3 epithelium. A, Representative serial tissue sections of normal cervical epithelium, immunostained for CD8 (left panel) and MAdCAM-1 (right panel). Arrows identify perivascular CD8+ cells (left panel) and MAdCAM-1 expression in corresponding vessels (right panel) (original magnification ×400). B, Representative CIN2/3 epithelium containing CD8+ cell infiltrates (left panel), with MAdCAM-1 expression in a serial section, same field (right panel) (original magnification ×100). C, Representative histologic sections of CIN2/3 epithelium with very sparse CD8 infiltrates (left panel) and MAdCAM-1 expression in a serial section, same field (right panel) (original magnification ×100). D, Quantification of MAdCAM-1 immunostaining in normal cervical epithelium (n = 7), normal cervical stroma (n = 8), CIN2/3 epithelium (n = 9), and CIN2/3 stroma (n = 9). E, Within-specimen correlation of the intensity of MAdCAM-1 and CD8 expression in normal and CIN2/3 mucosa. Each symbol represents the density of MAdCAM-1 (x coordinate) and CD8 (y coordinate) in the same field. The overall correlation is 0.738; correlation in CIN2/3 epithelium is 0.8833. p = 0.0031.