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. Author manuscript; available in PMC: 2011 Apr 13.
Published in final edited form as: FEBS J. 2010 Jan 22;277(5):1084–1096. doi: 10.1111/j.1742-4658.2009.07537.x

Figure 2. Emerging signaling pathways and vascular processes controlled by the CCM proteins.

Figure 2

(A)Cadherins, HEG1 and integrins are three transmembrane receptors connected to CCM proteins or functions. All three receptors are already known to play in different steps of vessel morphogenesis. Possible cross-talks between their dependent signaling pathways through CCM proteins are represented by arrows.

(B)CCM2 is a scaffold for small GTPases of the Rho family and for p38MAPK kinase. It is involved in actin cytoskeleton remodeling through scaffolfing of Rac, activation of the p38 MAPK kinase pathway and proteosomal degradation of RhoA. CCM2 could also be involved directly or indirectly in Cdc42 activation. As a result, cell-cell junctions, cell polarity and lumen formation are likely dependent on CCM2 signaling.