Analysis of in vitro transcribed RNA standards processed on-chip using one-step RT-PCR. (A) Representative electropherograms shows that each RNA standard (100 copies each) can be accurately identified in the presence of all four primer pairs using the microdevice. A negative control containing no template verifies the absence of carryover between analyses. (B) Sensitivity analysis, as a function of initial RNA template concentrations, shows that the microdevice can detect hCoV-OC43, FLUBV, FLUAV, and hMPV RNA at 25, 50, 100, and 100 copies respectively with S/N > 5 (n=3).