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Model for internalization of the HKβ by association with the tetraspanin CD63. CD63 may be an adaptor protein that facilitates the extended trafficking of associated proteins from the cell surface all of the way through to the late endosomal–lysosomal compartment by sequential interactions with AP-2 and AP-3. It is possible also that association with CD63 prevents the rapid recycling of associated proteins from internal compartments to the cell surface.
