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. Author manuscript; available in PMC: 2011 Dec 1.
Published in final edited form as: Bipolar Disord. 2010 Dec;12(8):813–824. doi: 10.1111/j.1399-5618.2010.00882.x

Table 2.

Top 10 functional pathways identified by microarray analysis as differing significantly between bipolar disorder subjects and healthy controls

Rank Pathway Cell process p-value Differentially expressed genes, n Genes or proteins in pathway, n
1 Oxidative phosphorylation/electron transport chain Energy metabolism 8.64E-07 24 85
2 Development: Notch signaling pathway Response to extracellular stimulus 2.73E-04 12 40
3 Transcription: NF-kB signaling pathway Transcription, immune response 5.36E-04 11 37
4 Development: NOTCH1-mediated pathway for NF-KB activity modulation Transcription, response to extracellular stimulus 6.18E-04 10 32
5 Bacterial infections in cystic fibrosis airways Lung diseases/cystic fibrosis 7.20E-04 12 44
6 Development: EPO-induced Jak-STAT pathway Apoptosis, response to extracellular stimulus 1.35E-03 10 35
7 Apoptosis and survival: Lymphotoxin-beta receptor signaling Apoptosis, immune response 1.39E-03 11 41
8 Apoptosis and survival: BAD phosphorylation Apoptosis and survival 1.71E-03 10 36
9 Immune response: MIF – the neuroendocrine-macrophage connector Immune response 2.07E-03 9 31
10 Apoptosis and survival: Anti-apoptotic TNFs/NF-kB/Bcl-2 pathway Apoptosis and survival 4.84E-03 10 41