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. Author manuscript; available in PMC: 2011 Dec 1.
Published in final edited form as: Bipolar Disord. 2010 Dec;12(8):813–824. doi: 10.1111/j.1399-5618.2010.00882.x

Table 4.

Comparison of microarray and quantitative real-time reverse transcription polymerase chain reaction (qRT-PCR) results for selected electron transport chaingenes

Gene symbol Fold-change qRT-PCR p-value qRT-PCR Fold-change microarray p-value microarray
Complex I (NADH dehydrogenase)a
NDUFA1–nuclear encoded 2.35 fold 0.0069 1.49 fold 0.0068
NDUFB3–nuclear encoded 2.79 fold 0.0128 1.80 fold 0.0022
NDUFS4–nuclear encoded 2.78 fold 0.0011 1.67 fold 0.0007
NDUFS5–nuclear encoded 2.58 fold 0.0066 1.94 fold 0.0024
MT-ND2 1.96 fold 0.0361 n/a n/a
Complex II (succinate dehydrogenase)
SDHD–nuclear encoded 1.98 fold 0.0128 (-)1.64 0.0125
Complex III (ubiquinol cytochrome c reductase)
UQCRB–nuclear encoded 4.78 fold 6.98E-05 1.62 fold 0.0007
UQCRQ–nuclear encoded 1.28 fold 0.4270 (NS) 1.63 fold 0.002
MT-CYBb 1.23 fold 0.4408 (NS) n/a n/a
Complex IV (cytochrome c oxidase)
COX6C–nuclear encoded 1.91 fold 0.0546 (NS) 2.16 fold 0.0036
COX7B–nuclear encoded 3.86 fold 0.0032 2.19 fold 0.0097
COX7C–nuclear encoded 2.24 fold 0.0055 1.56 fold 0.0039
MT-COIc 3.06 fold 0.0002 n/a n/a
Complex V (ATP synthase)
ATP5H–nuclear encoded 1.52 fold 0.1821 (NS) 1.33 fold 0.0053
ATP5I–nuclear encoded 1.35 fold 0.2856 (NS) 1.33 fold 0.0385
MT-ATP6 2.38 fold 0.0066 n/a n/a

NDUFA1 = NADH dehydrogenase flavoprotein A1; NDUFB3 = NADH dehydrogenase flavoprotein B3; NDUFS4 = NADH dehydrogenase flavoprotein S4; NDUFS5 = NADH dehydrogenase flavoprotein S5; MT-ND2 = mitochondrially encoded NADH dehydrogenase 2; SDHD = succinate dehydrogenase complex, subunit D; UQCRB = ubquinol-cytochrome c reductase binding protein; UQCRQ = ubiquinol-cytochrome c reductase, complex III subunit VII; MT-CYB = mitochondrially encoded cytochrome b; COX6C = cytochrome c oxidase subunit VIc; COX7C = cytochrome c oxidase subunit VIIb; COX7C = cytochrome c oxidase subunit VIIc; MT-COI = mitochondrially encoded cytochrome c oxidase I; ATP5H = ATP synthase, FO, subunit d; ATP5I = ATP synthase, FO, subunit E; MT-ATP6 = mitochondrially encoded ATP synthase 6.

a

Also known as NADH-coenzyme Q oxidoreductase.

b

Also known as CYTB.

c

Also known as COX1.