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. Author manuscript; available in PMC: 2011 Jun 1.
Published in final edited form as: Pediatr Res. 2010 Jun;67(6):579–584. doi: 10.1203/PDR.0b013e3181dc240f

Fig 3.

Fig 3

IGF-1 at the low dose protected against LPS-induced cell death in the gray matter. LPS treatment resulted in an increased number of pyknotic cells in the cortex at P6 (B, layer II and III) and P8 (E, cingular subcortex), compared to the controls (A&D). IGF-1 significantly decreased the number of pyknotic cells at both P6 and P8 (C&F). Pyknotic cells (arrow heads) are distinguished from PMNs (arrows) by their condensed/fragmented nuclei as shown in the inserts in E (PMN, up left; pyknotic cell, up right). The pyknotic cells shown in B were also positive for TUNEL (G). Pyknotic cell counting is shown in H (open bars: control; black bars: LPS; striped bars: LPS+IGF-1). Scale bar: 50 μm. *p<0.01 vs LPS treatment.