Table 4. Association between genotype risk score (GRS) and MI.
| GRS | Cases N=1911 |
Controls N=2024 |
Odds ratios (95% CI) | |
|---|---|---|---|---|
| Unadjusted | Adjusted* | |||
| 1 | 16 (0.8) | 26 (1.3) | 1.0 | 1.0 |
| 2 | 83 (4.3) | 138 (6.8) | 0.98 (0.49-1.93) | 1.09 (0.51-2.34) |
| 3 | 344 (18.0) | 423 (20.9) | 1.32 (0.70-2.50) | 1.54 (0.75-3.15) |
| 4 | 684 (35.8) | 768 (37.9) | 1.45 (0.77-2.72) | 1.69 (0.83-3.42) |
| 5 | 618 (32.3) | 519 (25.6) | 1.93 (1.03-3.65) | 2.31 (1.14-4.69) |
| 6 | 166 (8.7) | 150 (7.4) | 1.80 (0.93-3.48) | 2.01 (0.96-4.20) |
| Per allele | 1.18 (1.11-1.25) | 1.19 (1.12-1.27) | ||
| P for trend | 4.83*10-8 | 1.49*10-7 | ||
In GRS analyses, individuals with missing genotyping were excluded
*
Adjusted for age, sex, area of residence, waist-to-hip ratio, smoking, alcohol consumption, physical activity and family history of coronary heart disease