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. Author manuscript; available in PMC: 2011 May 1.
Published in final edited form as: J Nucl Med. 2010 Apr 15;51(Suppl 1):128S–136S. doi: 10.2967/jnumed.109.068239

FIGURE 3.

FIGURE 3

Ablation of teratoma formation with HSVttk as both PET reporter gene and suicide gene. (A) Immunodeficient animals were injected with undifferentiated mouse ESCs stably expressing triple-fusion reporter gene construct (Fluc-mRFP-HSVttk). Treatment of control animals with saline resulted in formation of multiple teratomas by week 5. (B) In contrast, study animals treated with ganciclovir (50 mg/kg of body weight) for 2 wk showed abrogation of both bioluminescence and PET signals. (Reprinted with permission of (56).)