Table 2.
Birth year-adjusted associations between oxidative stress and inflammatory-mediated pathway polymorphisms and breast cancer risk in the US Radiologic Technologists Study
| Gene | Entrez SNP IDa | Genotype | Cases (%)(n = 859) | Controls (%)(n = 1,083) | ORb | 95% CI | p-value | p-trendc | |
|---|---|---|---|---|---|---|---|---|---|
| IFNG | rs1861494 | AA | 429 (51) | 548 (51) | 1.0 | ||||
| AG | 342 (40) | 429 (40) | 1.0 | 0.8 | 1.2 | 0.8 | |||
| GG | 74 (9) | 89 (8) | 1.1 | 0.8 | 1.5 | 0.7 | 0.7 | ||
| IFNG | rs2069705 | TT | 369 (45) | 478 (45) | 1.0 | ||||
| TC | 352 (43) | 468 (44) | 1.0 | 0.8 | 1.2 | 0.8 | |||
| CC | 105 (13) | 119 (11) | 1.1 | 0.9 | 1.5 | 0.4 | 0.6 | ||
| IL1B | rs16944 | CC | 370 (45) | 456 (42) | 1.0 | ||||
| TC | 352 (43) | 494 (46) | 0.9 | 0.7 | 1.1 | 0.2 | |||
| TT | 98 (12) | 127 (12) | 1.0 | 0.7 | 1.3 | 0.7 | 0.4 | ||
| IL1B | rs1143634 | CC | 463 (56) | 636 (59) | 1.0 | ||||
| TC | 314 (38) | 385 (36) | 1.1 | 0.8 | 1.4 | 0.3 | |||
| TT | 57 (7) | 53 (5) | 1.5 | 1.0 | 2.2 | 0.05 | 0.05 | ||
| IL4 | rs2243250 | CC | 616 (74) | 750 (70) | 1.0 | ||||
| TC | 206 (25) | 289 (27) | 0.9 | 0.7 | 1.1 | 0.2 | |||
| TT | 16 (2) | 35 (3) | 0.5 | 0.3 | 1.0 | 0.05 | 0.08 | ||
| IL4d | rs2243248 | TT | 721 (86) | 928 (89) | 1.0 | ||||
| GT/GG | 115 (14) | 120 (11) | 1.2 | 0.9 | 1.6 | 0.1 | 0.2 | ||
| IL4 | rs2070874 | CC | 600 (73) | 763 (71) | 1.0 | ||||
| TC | 206 (25) | 288 (27) | 0.9 | 0.7 | 1.1 | 0.4 | |||
| TT | 12 (1) | 30 (3) | 0.5 | 0.3 | 1.0 | 0.05 | 0.03 | ||
| IL6e | rs1800795 | GG | 274 (33) | 379 (35) | 1.0 | ||||
| CG | 408 (49) | 487 (45) | 1.2 | 0.9 | 1.4 | 0.2 | |||
| CC | 156 (19) | 211 (20) | 1.0 | 0.8 | 1.3 | 0.9 | 0.6 | ||
| IL6f | rs1800797 | GG | 272 (33) | 393 (37) | 1.0 | ||||
| GA | 395 (48) | 478 (45) | 1.2 | 1.0 | 1.5 | 0.09 | |||
| AA | 151 (18) | 199 (19) | 1.1 | 0.8 | 1.4 | 0.5 | 0.3 | ||
| IL10 | rs1800871 | CC | 487 (59) | 590 (56) | 1.0 | ||||
| TC | 288 (35) | 394 (37) | 0.9 | 0.7 | 1.1 | 0.2 | |||
| TT | 54 (7) | 75 (7) | 0.9 | 0.6 | 1.3 | 0.5 | 0.2 | ||
| IL10 | rs1800896 | AA | 219 (26) | 322 (30) | 1.0 | ||||
| GA | 417 (50) | 530 (50) | 1.2 | 0.9 | 1.4 | 0.2 | |||
| GG | 200 (24) | 230 (21) | 1.3 | 1.0 | 1.7 | 0.06 | 0.06 | ||
| IL12B | rs3212227 | AA | 537 (64) | 697 (64) | 1.0 | ||||
| CA | 263 (31) | 335 (31) | 1.0 | 0.8 | 1.2 | 0.9 | |||
| CC | 36 (4) | 50 (5) | 0.9 | 0.6 | 1.5 | 0.8 | 0.9 | ||
| NFKB1 | rs230521 | GG | 321 (38) | 401 (37) | 1.0 | ||||
| CG | 400 (47) | 496 (46) | 1.0 | 0.8 | 1.2 | 0.9 | |||
| CC | 127 (15) | 179 (17) | 0.9 | 0.7 | 1.2 | 0.4 | 0.5 | ||
| NFKBIE | rs730775 | TT | 291 (34) | 351 (33) | 1.0 | ||||
| CT | 425 (50) | 547 (51) | 0.9 | 0.8 | 1.1 | 0.5 | |||
| CC | 140 (16) | 182 (17) | 0.9 | 0.7 | 1.2 | 0.6 | 0.5 | ||
| NOS2A | rs944722 | AA | 309 (37) | 407 (38) | 1.0 | ||||
| GA | 400 (48) | 490 (45) | 1.1 | 0.9 | 1.3 | 0.5 | |||
| GG | 123 (15) | 182 (17) | 0.9 | 0.7 | 1.2 | 0.3 | 0.6 | ||
| NOS2A | rs2297518 | CC | 526 (63) | 675 (63) | 1.0 | ||||
| TC | 281 (34) | 352 (34) | 1.0 | 0.8 | 1.2 | 0.8 | |||
| TT | 30 (4) | 45 (4) | 0.9 | 0.5 | 1.4 | 0.5 | 0.8 | ||
| NOS3 | rs1799983 | GG | 412 (50) | 506 (47) | 1.0 | ||||
| TG | 329 (40) | 449 (42) | 0.9 | 0.7 | 1.1 | 0.3 | |||
| TT | 77 (9) | 122 (11) | 0.8 | 0.6 | 1.1 | 0.1 | 0.09 | ||
| NOS3 | rs1549758 | CC | 418 (50) | 516 (48) | 1.0 | ||||
| TC | 345 (41) | 447 (42) | 1.0 | 0.8 | 1.2 | 0.6 | |||
| TT | 72 (9) | 114 (11) | 0.8 | 0.6 | 1.1 | 0.1 | 0.2 | ||
| PTGS1 | rs5788 | CC | 615 (76) | 799 (74) | 1.0 | ||||
| CA | 181 (22) | 260 (24) | 0.9 | 0.7 | 1.1 | 0.3 | |||
| AA | 17 (2) | 20 (2) | 1.1 | 0.6 | 2.1 | 0.8 | 0.5 | ||
| PTGS2 | rs5277 | GG | 610 (73) | 794 (74) | 1.0 | ||||
| GC | 198 (24) | 264 (24) | 1.0 | 0.8 | 1.2 | 0.8 | |||
| CC | 23 (3) | 20 (2) | 1.5 | 0.8 | 2.7 | 0.2 | 0.6 | ||
| PTGS2 | rs5275 | TT | 387 (47) | 437 (40) | 1.0 | ||||
| TC | 348 (42) | 501 (46) | 0.8 | 0.6 | 0.9 | 0.01 | |||
| CC | 96 (12) | 144 (13) | 0.8 | 0.6 | 1.0 | 0.06 | 0.01 | ||
| SOD1d | rs2070424 | AA | 712 (85) | 931 (86) | 1.0 | ||||
| GA/GG | 124 (15) | 149 (14) | 1.1 | 0.8 | 1.4 | 0.5 | 0.4 | ||
| SOD2 | rs4880 | CC | 206 (24) | 285 (26) | 1.0 | ||||
| CT | 422 (50) | 539 (50) | 1.1 | 0.9 | 1.3 | 0.5 | |||
| TT | 217 (26) | 256 (24) | 1.2 | 0.9 | 1.5 | 0.2 | 0.2 | ||
| SOD2 | rs2758346 | AA | 210 (25) | 289 (27) | 1.0 | ||||
| GA | 416 (50) | 534 (49) | 1.1 | 0.9 | 1.3 | 0.5 | |||
| GG | 210 (25) | 256 (24) | 1.1 | 0.9 | 1.5 | 0.3 | 0.3 | ||
| SOD3 | rs2855262 | CC | 325 (40) | 431 (40) | 1.0 | ||||
| TC | 398 (49) | 516 (48) | 1.0 | 0.8 | 1.2 | 0.8 | |||
| TT | 81 (11) | 128 (12) | 0.9 | 0.7 | 1.3 | 0.7 | 0.9 | ||
| TNF | rs1800629 | GG | 560 (69) | 714 (67) | 1.0 | ||||
| GA | 229 (28) | 313 (29) | 0.9 | 0.8 | 1.1 | 0.5 | |||
| AA | 28 (3) | 36 (3) | 1.0 | 0.6 | 1.6 | 0.9 | 0.6 | ||
| TNFd | rs361525 | GG | 763 (91) | 986 (91) | 1.0 | ||||
| GA/AA | 79 (9) | 96 (9) | 1.1 | 0.8 | 1.5 | 0.7 | 0.9 | ||
| TNFd | rs1799724 | CC | 682 (82) | 898 (84) | 1.0 | ||||
| TC/TT | 148 (18) | 174 (16) | 1.1 | 0.9 | 1.4 | 0.4 | 0.3 | ||
Bolded p-trend values indicate significance ≤ 0.05
a
Entrez SNP reference ID number (http://www.ncbi.nlm.nih/gov/entry/query.fcgi?db=snp)
b
Adjusted for year of birth
c
1 df test across genotypes
d
Dominant model assumed due to prevalence of rare homozygotes <2%
e
p-value for Hardy–Weinberg equilibrium = 0.04
f
p-value for Hardy–Weinberg equilibrium = 0.03