Table 3.

Associations of rs6028466, rs621559 and rs654128 with bladder cancer risk

	Overall				Never Smoker				Ever Smoker
Genotype	Case	Control	OR (95% CI)	P	Case	Control	OR (95% CI)	P	Case	Control	OR (95% CI)	P
rs6028466
GG	867	848	Ref.		230	357	Ref.		636	491	Ref.
GA	102	107	0.93 (0.69–1.25)	0.61	26	49	0.82 (0.49–1.36)	0.44	76	58	0.93 (0.69–1.25)	0.62
AA	0	2	N/A*		0	1	N/A		0	1	N/A
Additive			N/A				N/A				N/A
Dominant (GA+AA vs. GG)			0.91 (0.68–1.22)	0.53			0.80 (0.49–1.33)	0.39			0.98 (0.67–1.42)	0.91
Recessive (AA vs. GG+GA)			N/A				N/A				N/A
rs621559
GG	837	822	Ref.		218	352	Ref.		618	470	Ref.
GA	127	123	0.98 (0.74–1.29)	0.87	35	48	1.17 (0.73–1.87)	0.51	92	75	0.89 (0.63–1.25)	0.49
AA	4	12	0.39 (0.12–1.23)	0.11	3	7	0.65 (0.17–2.57)	0.54	1	5	N/A
Additive			0.89 (0.70–1.14)	0.37			1.03 (0.70–1.53)	0.86			N/A
Dominant (GA+AA vs. GG))			0.93 (0.71–1.21)	0.59			1.10 (0.70–1.73)	0.67			0.84 (0.60–1.18)	0.32
Recessive (AA vs. GG+GA)			0.39 (0.12–1.23)	0.11			0.64 (0.16–2.51)	0.52			N/A
rs654128
GG	695	701	Ref.		178	298	Ref.		517	403	Ref.
GT	243	235	1.06 (0.86–1.32)	0.57	68	100	1.14 (0.80–1.64)	0.47	174	135	1.02 (0.78–1.34)	0.86
TT	31	21	1.62 (0.91–2.89)	0.10	10	9	1.80 (0.71–4.52)	0.21	21	12	1.55 (0.74–3.20)	0.25
Additive			1.13 (0.95–1.36)	0.17			1.21 (0.90–1.63)	0.21			1.09 (0.87–1.37)	0.43
Dominant (GT+TT vs. GG)			1.11 (0.90–1.36)	0.33			1.20 (0.85–1.69)	0.31			1.07 (0.82–1.38)	0.63
Recessive (TT vs. GG+GT)			1.60 (0.90–2.84)	0.11			1.74 (0.69–4.35)	0.24			1.54 (0.74–3.20)	0.25

^*The number of homozygous variant genotype was ≤ in both cases and controls, only dominant model was applied.