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. Author manuscript; available in PMC: 2012 Mar 1.
Published in final edited form as: Cancer Res. 2011 Mar 1;71(5):1584–1596. doi: 10.1158/0008-5472.CAN-10-3166

Figure 4.

Figure 4

Myometrial invasion by endometrial adenocarcinoma in adult APCcko mice. CD133 expression, which is highly expressed in human endometrial carcinoma, was detected at higher levels in endometrial tumors of APCcko mice compared with controls (Panels A & B). Inset in Panel B is a higher magnification of area boxed in white dashed line. H&E sections of 8 month-old APCcko uteri with endometrial adenocarcinoma showing fully formed endometrial glands (arrows) present in the myometrium (M) (Panels C–D). (Panels E & F) Colocalization of αSMA (red, a smooth muscle specific marker) and Cytokeratin 8 (ck, green, an epithelial specific marker) confirmed the presence of endometrial glands (white arrows) in the myometrium. Control uteri are shown in Panels G & H. White dotted line in Panel C shows demarcation of smooth muscle layer from the endometrial stromal compartment. Bar equals 50 μm.