Table 5. Embryos and malformations resulting from matings of GT1AS heterozygotes together.
| GT1AS × GT1AS (10 gestations, 72 embryos)
|
GT1AS × GT1AS (9 gestations, 61 embryos)
|
|||
|---|---|---|---|---|
| NT Embryos | GT1AS embryos | Specific malformations | No. (percent of all embryos)* | |
| No. of embryos | n = 21 | n = 51 | Body mass < 70% control | 19 (31.1) |
| Percent total embryos | 29 | 71† | Microphthalmia | 3 (4.9) |
| No. malformed, % | 0 (0) | 18 (35.3)‡ | Caudal regression | 6 (9.8) |
| No. not malformed, % | 21 (100) | 33 (64.7) | Absent head | 4 (6.6) |
| — | — | — | Micrognathia | 1 (1.6) |
*
Embryos with malformations typically had more than one type of malformation.
†
Approximates the calculated ideal value of 75% GT1AS transgenic.
‡
P < 0.01 vs. NT.