Table 3.
Association of HLA-DRB1 and -DQB1 genotypes (frequencies >5% in either cases or controls) with LADA
| LADAa | Control subjectsa | OR (95% CI) | p value | |
|---|---|---|---|---|
| DRB1 genotype | ||||
| *0301/*0401 | 62 (0.164) | 12 (0.037) | 5.14 (2.68–10.69) | 1.3×10−8 |
| *0301/*0301 | 34 (0.090) | 7 (0.021) | 4.51 (1.93–12.23) | 7.6×10−5 |
| *0301/*0701 | 29 (0.077) | 11 (0.034) | 2.38 (1.13–5.38) | 0.014 |
| *0401/*0701 | 22 (0.058) | 14 (0.043) | 1.38 (0.66–2.97) | 0.39 |
| *0701/*1501-06 | 1 (0.003) | 17 (0.052) | 0.05 (0.001–0.31) | 2.9×10−5 |
| DQB1 genotype | ||||
| *0201/*0302 | 73 (0.194) | 11 (0.034) | 6.88 (3.54–14.68) | 1.2×10−11 |
| *0201/*0201 | 38 (0.101) | 7 (0.021) | 5.11 (2.21–13.77) | 9.4×10−6 |
| *0201/*0202 | 22 (0.058) | 8 (0.024) | 2.47 (1.04–6.51) | 0.038 |
| *0201/*0501 | 19 (0.050) | 6 (0.018) | 2.84 (1.07–8.79) | 0.024 |
| *0302/*0302 | 19 (0.050) | 6 (0.018) | 2.84 (1.07–8.79) | 0.024 |
| *0201/*0301 | 17 (0.045) | 17 (0.052) | 0.86 (0.41–1.83) | 0.73 |
| *0301/*0602 | 3 (0.008) | 22 (0.067) | 0.11 (0.02–0.38) | 1.7×10−5 |
All OR were calculated as presence of the genotype in question vs all other genotypes and are presented as LADA compared with control subjects.
a
Data are given as number of individuals (frequency).