Table 4.
Association of HLA-DRB1_DQB1 haplotypes (frequencies >5% in either cases or controls) with LADA
Haplotype | LADAa | Control subjectsa | OR (95% CI) | p value |
---|---|---|---|---|
*0301_*0201 | 234 (0.310) | 83 (0.127) | 3.08 (2.32–4.12) | 1.2×10−16 |
*0401_*0302 | 128 (0.169) | 48 (0.073) | 2.57 (1.80–3.73) | 4.5×10−8 |
*0701_*0202 | 81 (0.107) | 64 (0.098) | 1.11 (0.77–1.59) | 0.60 |
*0101_*0501 | 52 (0.069) | 64 (0.098) | 0.68 (0.46–1.02) | 0.052 |
*0401_*0301 | 49 (0.065) | 47 (0.072) | 0.90 (0.58–1.39) | 0.60 |
*1501-06_*0602 | 25 (0.033) | 90 (0.138) | 0.21 (0.13–0.34) | 4.2×10−13 |
*1101(04)_*0301 | 13 (0.017) | 43 (0.066) | 0.25 (0.12–0.48) | 3.4×10−6 |
All OR are calculated under the multiplicative model and are presented as LADA vs control subjects
Data are given as number of chromosomes (frequency)