Figure 4.
A: Effect of iloprost (1 μM, n = 9) or its vehicle (CONTROL, saline, n = 9) on cAMP levels in rabbit erythrocytes. In some studies erythrocytes were incubated with the IP receptor antagonist CAY10441 alone (CAY, 10 μM, n = 5) or were preincubated with CAY10441 (n = 5) or the β-receptor antagonist, propranolol (PROP, 10 μM, n = 4) before the addition of iloprost. B: Effect of isoproterenol (ISO, 1 μM, n = 9) or its vehicle (CONTROL, saline, n = 9) on cAMP levels in rabbit erythrocytes. In some studies erythrocytes were incubated with the β-receptor antagonist, propranolol alone (PROP, 10 μM, n = 5) or were preincubated with PROP (n = 5) or the IP receptor antagonist CAY10441 (CAY, 10 μM, n = 4) before the addition of ISO. Values are means ± SE. *p < 0.01 compared to all other groups.