Table 2. Cocaine-Induced Changes in Mean Arterial Pressure and Heart Rate at the Time of DM CocE Administration.

Mean arterial pressure	M1	F1	M2	F2
Baseline MAP (mm Hg)a	95.4 (2.2)	94.4 (1.7)	86.4 (8.1)	96.7 (0.9)
Dosing condition	MAP (mm Hg) 10-min after cocaineb
PBS	128.5	128.4	148.9	170.3
0.032 mg/kg DM CocE	140.6	126.3	ND	ND
0.1 mg/kg DM CocE	141.9	131.5	ND	ND
0.32 mg/kg DM CocE	127.9	125.6	140.0	160.3
1.0 mg/kg DM CocE	128.8	132.1	ND	170.0
3.2 mg/kg DM CocE	128.4	125.7	160.8	161.0
Heart rate	M1	F1	M2	F2
Baseline heart rate (b.p.m.)a	135.2 (5.4)	142.4 (2.4)	83.5 (7.9)	151.4 (4.1)
Dosing condition	HR (b.p.m.) 10-min after cocaineb
PBS	130.2	170.4	104.4	179.3
0.032 mg/kg DM CocE	188.7	166.8	ND	ND
0.1 mg/kg DM CocE	199.9	165.1	ND	ND
0.32 mg/kg DM CocE	141.4	170.0	115.5	147.7
1.0 mg/kg DM CocE	133.1	159.6	ND	183.8
3.2 mg/kg DM CocE	169.9	168.3	116.1	180.3

Abbreviation: ND, not determined.

^aValues represent the mean±SEM MAP or HR for the 15-min periods before i.v. administration of 3.2 mg/kg cocaine (M1, F1, and F2) or 1.0 mg/kg cocaine (M2) across dosing conditions.

^bValues represent the MAP or HR for the 1-min period immediately before the administration of PBS or DM CocE.