Scheme 1.
Synthesis of bisubstrate analogs (1-7). The shaded circle represents wang resin (solid phase support). The H4-20mer peptide sequence is as follows. NH2-SGRGKGGKGLGKGGAKRNRA-COOH
Synthesis of bisubstrate analogs (1-7). The shaded circle represents wang resin (solid phase support). The H4-20mer peptide sequence is as follows. NH2-SGRGKGGKGLGKGGAKRNRA-COOH