Table 4. Association of hypertension categories with CVD mortality in women and men combined.
Hypertensive group | |||||
Total | Normotensive | Untreated hypertensive | Poorly treated hypertensive | Well treated hypertensive | |
Using subset with no missing values for any covariable/hypertensive group | |||||
N | 4796 | 1264 | 2427 | 941 | 164 |
CVD deaths | 107 | 15 | 59 | 29 | 4 |
Hazard ratios (95% CI) | |||||
Model 1* | - | 1 | 1.60 (0.90, 2.85) | 1.98 (1.05, 3.72) | 1.85 (0.61, 5.58) |
Model 2* | - | 1 | 1.66 (0.93, 2.96) | 2.09 (1.09, 4.00) | 1.70 (0.56, 5.22) |
Model 3* | - | 1 | 1.09 (0.54, 2.20) | 1.29 (0.58, 2.89) | 1.67 (0.55, 5.12) |
Using imputed data for missing values (20 imputations) | |||||
N** | 6476 | 1688 | 3328 | 1245 | 215 |
CVD deaths** | 158 | 21 | 92 | 39 | 6 |
Hazard ratios (95% CI) | |||||
Model 1* | - | 1 | 1.80 (1.10, 2.94) | 1.97 (1.14, 3.39) | 2.04 (0.82, 5.08) |
Model 2* | - | 1 | 1.91 (1.17, 3.12) | 2.13 (1.23, 3.71) | 1.97 (0.78, 4.94) |
Model 3* | - | 1 | 1.19 (0.65, 2.18) | 1.26 (0.64, 2.47) | 1.92 (0.77, 4.83) |
*Model 1: adjusted for sex, age (as time variable in Cox model).
Model 2: additionally adjusted for BMI, smoking, physical activity, LDL cholesterol, HDL cholesterol, triglycerides (log scale), glucose (log scale), insulin (log scale), fathers occupational social class (childhood social class), own adult occupational social class.
Model 3: additionally adjusted for systolic and diastolic blood pressure (BP).
**Imputed numbers per group and associated numbers of events are means over 20 imputed datasets.