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. 2011 Apr 13;6(4):e17792. doi: 10.1371/journal.pone.0017792

Table 4. Association of hypertension categories with CVD mortality in women and men combined.

Hypertensive group
Total Normotensive Untreated hypertensive Poorly treated hypertensive Well treated hypertensive
Using subset with no missing values for any covariable/hypertensive group
N 4796 1264 2427 941 164
CVD deaths 107 15 59 29 4
Hazard ratios (95% CI)
Model 1* - 1 1.60 (0.90, 2.85) 1.98 (1.05, 3.72) 1.85 (0.61, 5.58)
Model 2* - 1 1.66 (0.93, 2.96) 2.09 (1.09, 4.00) 1.70 (0.56, 5.22)
Model 3* - 1 1.09 (0.54, 2.20) 1.29 (0.58, 2.89) 1.67 (0.55, 5.12)
Using imputed data for missing values (20 imputations)
N** 6476 1688 3328 1245 215
CVD deaths** 158 21 92 39 6
Hazard ratios (95% CI)
Model 1* - 1 1.80 (1.10, 2.94) 1.97 (1.14, 3.39) 2.04 (0.82, 5.08)
Model 2* - 1 1.91 (1.17, 3.12) 2.13 (1.23, 3.71) 1.97 (0.78, 4.94)
Model 3* - 1 1.19 (0.65, 2.18) 1.26 (0.64, 2.47) 1.92 (0.77, 4.83)

*Model 1: adjusted for sex, age (as time variable in Cox model).

Model 2: additionally adjusted for BMI, smoking, physical activity, LDL cholesterol, HDL cholesterol, triglycerides (log scale), glucose (log scale), insulin (log scale), fathers occupational social class (childhood social class), own adult occupational social class.

Model 3: additionally adjusted for systolic and diastolic blood pressure (BP).

**Imputed numbers per group and associated numbers of events are means over 20 imputed datasets.

Numbers per group differ slightly between Tables 2, 3, 4 as time to event and the censoring variable are included as a covariable in the imputation prediction model.