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. 2011 Apr 1;7(3):347–363. doi: 10.7150/ijbs.7.347

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© Ivyspring International Publisher. This is an open-access article distributed under the terms of the Creative Commons License (http://creativecommons.org/licenses/by-nc-nd/3.0/). Reproduction is permitted for personal, noncommercial use, provided that the article is in whole, unmodified, and properly cited.

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Effects of Big-h3 Knockdown on cell proliferation and radiation induced apoptosis. (A). Validation of three anti-Big-h3 siRNA (siRNA-1, siRNA-2 and siRNA-3) and a control non-targeting siRNA (si-NC) in transfected NIH3T3 cells and EL4 cells 48 hours after transfection. Data showed the Mean fluorescence intensity level. (B). Knockdown of Big-h3 (si-Big-h3), but not KD of nonspecific control (si-NC), attenuated the apoptosis rate of the NIH3T3 cells after IR, which mimics the effects of miR-21 over-expression. (C). Knockdown of Big-h3 (si-Big-h3) attenuated, but not fully wiped off, the pro-apoptosis role of miR-21 inhibitor (miR-21 ASO) in EL4 cells. *: P < 0.05.