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RT-PCR analysis of IGF-II and IGFR-I in samples of DMS-153 SCLC tumors. PCR products were of the expected sizes of 538 bp for IGF-II, 447 bp for IGFR-I, and 459 bp for β-actin. Lane M, 100-bp DNA molecular weight marker; lanes 1-5, untreated animals; lanes 6-9, animals treated with RC-3949-II; lanes 10-13, animals treated with JV-1-65; lanes 14-16, animals treated with RC-3940-II + JV-1-65; lanes 17-20, animals treated with JV-1-63.
