Time to hospitalization for infection (HFI). Group 1 medications include hydroxycholoroquine, sulfasalazine, auranofin, injectable gold, and penicillamine. Group 2 medications include methotrexate, leflunomide, azathioprine, cyclophosphamide, cyclosporine, and anakinra. Group 3 medications include etanercept, infliximab and adalimumab.