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. Author manuscript; available in PMC: 2011 Nov 1.
Published in final edited form as: Future Microbiol. 2011 Jan;6(1):57–71. doi: 10.2217/fmb.10.153

Figure 3. Outgroup analysis to deduce ancestral bases for Mycobacterium leprae single nucleotide polymorphism positions.

Figure 3

(A) A polymorphic site is shown and comparisons performed between different Mycobacterium leprae strains and other actinobacteria which serve as an outgroup. The strain showing identity to the base occupying this site in the outgroup is considered to be closer to the MRCA. (B) The results of outgroup analysis at 28 sites defined by SNP and the bases occupying those sites in the TN (subtype 1A) or Br4923 (subtype 4P) strains and the outgroups. Note that not all genes are present in outgroup members. At the bottom the deduced ancestral base is shown (MRCA).

MRCA: Most recent common ancestor; SNP: Single nucleotide polymorphism.