Fig. 1.

Detection of VZV and SVV ORF 63 proteins in the cytoplasm of neurons in ganglia of a human latently infected with VZV and a rhesus macaque latently infected with SVV. Paraformal-dehyde-fixed, paraffin-embedded sections of thoracic ganglia from a VZV seropositive 46-year-old man (a) (Mahalingam et al. 1996) and from a rhesus macaque latently infected with SVV (b) (Messaoudi et al. 2009) were analyzed by immunohistochemistry using rabbit anti-VZV ORF 63. Both VZV and SVV ORF 63 proteins are located exclusively in the cytoplasm of neurons in the respective ganglia. The arrows indicate the location of ORF 63 protein in the neuronal cytoplasm. Figure 1a reprinted with permission of National Academy of Sciences, USA (Mahalingam et al. (1996); Copyright 1996 National Academy of Sciences. USA); and Fig. 2b PLoS pathogens (Messaoudi et al. 2009)