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. Author manuscript; available in PMC: 2012 Jan 7.
Published in final edited form as: Circ Res. 2011 Jan 7;108(1):98–112. doi: 10.1161/CIRCRESAHA.110.223586

Fig. 8.

Fig. 8

A. Sub- and supra-threshold DADs. Depending on the size and rate of rise of the Ca transient during the Ca wave(s), and the diastolic Ca-voltage coupling gain, a DAD can remain below or above the threshold to trigger an AP. B. DAD-repolarization interaction. DADs recorded from a paced isolated rabbit ventricular myocyte before (black traces) and after (red traces) exposure to isoproterenol. Depending on the timing, subthreshold DADs can cause APD prolongation (upper) and frank EADs (lower).