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. Author manuscript; available in PMC: 2012 Mar 1.
Published in final edited form as: Am J Transplant. 2011 Mar;11(3):613–618. doi: 10.1111/j.1600-6143.2010.03407.x

Figure 3. Increased frequency of high-quality dual-cytokine producing effector cells in sirolimus-treated macaques.

Figure 3

RM were treated with sirolimus or left untreated during both vaccination and boost with MVA (n=4 in each group). PBMCs isolated at each timepoint were stimulated with vaccinia virus and assessed for IFN-γ and TNF by ICCS. Percentage of CD3+ CD8+ T cells which produce both TNF and IFN-γ at day 0 of vaccination with MVA and in the weeks following MVA are shown; up to three replicates for each RM at each timepoint are depicted. (* p<0.05, ** p<0.01).