Table 1.

Association of genotype at VWF locations (A) c.-2527, B) (GT)_n and C) (GT)n plus c.-2527 with median levels of VWF in healthy controls from the MCMDM-1VWD study controlling for blood group.

Analysis	Genotype and ABO blood group	Mean age (SD)	n*	Median VWF:Ag level (IU/dL) (Range†)	p value
A) c.-2527G>A	All‡		1115
	G/G	40.7 (12.5)	162	96.5 (74.8–119.5)	0.961
	G/A	40.2 (11.9)	521	98.0 (77.0–120.0)
	A/A	40.5 (11.4)	432	96.0 (75.0–122.0)
	O		410
	G/G	41.6 (11.3)	51	84.0 (66.0–106.0)	0.747
	G/A	42.1 (12.5)	191	80.0 (64.0–98.0)
	A/A	41.2 (10.6)	168	78.5 (66.0–99.0)
	Non-O		678
	G/G	40.8 (13.1)	104	106.0 (81.0–133.0)	0.852
	G/A	39.3 (11.4)	319	107.0 (89.0–126.0)
	A/A	40.2 (12.0)	255	112.0 (86.0–129.0)
B) (GT)n	All		1105
	S/S	41.0 (11.5)	196	92.0 (70.3–114.5)	0.027
	S/L	40.3 (11.8)	555	97.0 (76.0–120.0)
	L/L	40.6 (12.3)	354	100.0 (78.0–125.0)
	O		408
	S/S	41.8 (11.0)	71	80.0 (62.0–99.0)	0.524
	S/L	42.0 (11.7)	199	80.0 (65.0–102.0)
	L/L	40.9 (11.6)	138	82.0 (67.8–101.3)
	Non-O		569
	S/S	41.1 (11.7)	118	101.0 (77.8–124.3)	0.020
	S/L	39.3 (11.8)	344	107.5 (86.0–127.0)
	L/L	40.7 (12.8)	207	114.0 (91.0–132.0)
C) c.-2527G>A & (GT)n	All		727
	S/S-G/G	41.3 (12.0)	110	92.0 (71.8–116.3)	0.314
	S/L-G/A	39.7 (11.7)	358	96.5 (77.8–120.0)
	L/L-A/A	40.7 (11.9)	259	98.0 (76.0–125.0)
	O		278
	S/S-G/G	41.5 (10.6)	39	84.0 (66.0–101.0)	0.714
	S/L-G/A	41.8 (12.0)	134	81.5 (65.8–104.0)
	L/L-A/A	40.8 (10.7)	105	85.0 (67.0–103.0)
	Non-O		432
	S/S-G/G	42.1 (12.5)	65	102.0 (76.5–134.5)	0.387
	S/L-G/A	38.6 (11.4)	219	107.0 (87.0–126.0)
	L/L-A/A	40.8 (12.9)	148	112.5 (88.0–130.0)

^*ABO blood group data were available for 1088 out of 1115 HC.

^†Range = 25^th–75^th percentile.

^‡All: all blood groups; O: blood group O only; Non-O: blood groups other than O.

SD: Standard deviation