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. Author manuscript; available in PMC: 2012 Jan 1.
Published in final edited form as: Anat Rec (Hoboken). 2010 Nov 16;294(1):132–144. doi: 10.1002/ar.21294

Figure 7.

Figure 7

The effect of PDTC (A,B) or UDCA (B,C) treatment on the TS muscle. Staining is H&E (20 μm calibration). Cross-sections obtained from caudal TS muscles from mature adult mdx mice treated chronically with vehicle (A) or PDTC (B). (A) Severely dystrophic caudal TS region of a 12.5 month old vehicle treated mdx mouse. Note the extensive fibrosis and densely stained cellular infiltrates, the relative lack of fiber cross sections, and the centrally located nucleus in the approximate middle of the section. (B) Caudal TS of a 12 month old PDTC treated mdx mouse. Note the elevated number of fibers and the apparent absence of centronucleation in this section. Cross sections obtained from the middle TS region of 2 month old mdx mice treated with either UDCA vehicle (C) or UDCA (D). Note the extensive cellular infiltration in (C) and the larger fiber cross sections with no cellular infiltrates in (D).