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Soluble guanylyl cyclase activation by nitric oxide (NO), carbon monoxide (CO), NO donors, and NO-independent heme-dependent soluble guanylyl cyclase (sGC) stimulators requires integrity of heme-moiety of sGC, whereas NO- and heme- independent sGC activators are more potent to activate sGC if heme moiety is on its oxidized (planar) state.
