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. Author manuscript; available in PMC: 2012 Mar 3.
Published in final edited form as: Epilepsia. 2011 Mar 3;52(3):e7–e11. doi: 10.1111/j.1528-1167.2011.02981.x

Figure 2. Ketogenic diet inhibits mTOR activation after KA-induced SE.

Figure 2

(A) Western blotting shows pS6 and total S6 expression in the hippocampus and neocortex at different time intervals after KA-induced SE in rats administered either KD or SD. Each lane represents protein isolated from a single animal.

(B) Quantitative summary of hippocampal pS6/S6 ratio, normalized to animals not treated with KA (Cont), demonstrates that KA-induced SE increased pS6 expression at 1d (***p<0.001) and 7d (*p<0.05), with return to baseline by 21d. KD did not affect the initial pS6 elevation, but completely blocked the elevation at 7d (**p<0.01).

(C) In neocortex, SE did not significantly increase pS6 expression. However, KD did reduce pS6 expression 7 and 21 days after KA-induced SE compared to SD (*p<0.05 for both). For KA experiments, n=8 for control group, n=7 for 1d SD and KD groups, n=10 for 7d SD and KD groups, and n=7 for 21d SD and KD groups.