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. Author manuscript; available in PMC: 2012 Mar 10.
Published in final edited form as: J Med Chem. 2011 Feb 7;54(5):1490–1510. doi: 10.1021/jm101535e

Scheme 5.

Scheme 5

Reagents: i. Fmoc-GABA-OH, PS-Carbodiimide, PS-DMAP, CH2Cl2; ii. (a) 30% Piperidine, CH2Cl2 (b) C11H23COCl, pyridine; iii. (a) H2, Pd(OH)2/C, MeOH, 60 psi (b) CF3COOH; iv. Glutaric anhydride, CH2Cl2; v. C11H23OH, HBTU, DMAP, TEA, DMF.