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. 2011 Mar 16;93(5):968–974. doi: 10.3945/ajcn.110.011064

FIGURE 1.

FIGURE 1

Mean (±SE) ratios of phosphatidylcholine docosahexaenoic acid to phosphatidylcholine (PtdCho-DHA/PtdCho) concentrations in plasma were highest in premenopausal women with no alleles of the rs12325817 single nucleotide polymorphism (SNP) in the PEMT gene. Plasma was obtained from healthy women and men who consumed a standardized diet that delivered 550 mg choline/70 kg body weight daily for 10 d. At the end of this period, blood was collected and the portion of PtdCho species containing DHA (pmol PtdCho-DHA/nmol PtdCho) was measured in plasma by using gas chromatography as described in Subjects and Methods. DNA was extracted from peripheral lymphocytes and genotyped for the PEMT SNP rs12325817 as described in Subjects and Methods. Filled bars represent all subjects (n = 20–27 per group), hatched bars represent subjects with no alleles of the PEMT SNP (6–8 per group), and open bars represent subjects with 2 alleles of the PEMT SNP (3–5 per group). *,**ANOVA: *P < 0.05, **P < 0.01.