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. 2011 Mar 16;93(5):968–974. doi: 10.3945/ajcn.110.011064

FIGURE 4.

FIGURE 4

Ratios of phosphatidylcholine docosahexaenoic acid to phosphatidylcholine (PtdCho-DHA/PtdCho) concentrations in plasma correlated with ratios of plasma S-adenosylmethionine (AdoMet) to S-adenosylhomocysteine (AdoHcy). Healthy volunteers consumed a standardized diet that delivered 550 mg choline/70 kg body weight daily for 10 d and then consumed a diet containing <50 mg choline/70 kg body weight daily for ≤42 d or until they developed liver or muscle dysfunction as described in Subjects and Methods. At the end of this period, blood was collected and the portion of PtdCho species containing DHA was measured in plasma by using gas chromatography as described in Subjects and Methods. Plasma AdoMet and AdoHcy concentrations were measured at the end of the low-choline phase of the study as described in Subjects and Methods. The correlation was assessed by using linear regression analysis (P = 0.0001, r = 0.716). n = 41.