TABLE 1.

Characteristics of subjects before and after weight loss¹

	Low-calorie diet (n = 9)		Low-carbohydrate diet (n = 9)		P value2
	Before	After	Before	After	Group	Time	Group × time
Age (y)	47 ± 123	—	42 ± 11	—	0.3614	—	—
Sex ratio (F:M)	6:3	—	7:2	—	1.0005	—	—
Liver biopsy
NAFLD activity score	4.3 ± 1.8	—	5.8 ± 1.6	—	0.1604	—	—
Fibrosis stage	1.3 ± 1.4	—	0.8 ± 0.9	—	0.3504	—	—
BMI (kg/m2)	34 ± 9	33 ± 9	36 ± 4	35 ± 4	0.545	<0.001	0.250
Body weight
Absolute (kg)	96 ± 21	92 ± 20	97 ± 14	92 ± 15	0.964	<0.001	0.363
Fractional (%)	100	96 ± 1	100	95 ± 1	0.239	<0.001	0.239
Total cholesterol (mg/dL)	207 ± 29	204 ± 53	212 ± 34	175 ± 24	0.607	0.242	0.498
Triglycerides (mg/dL)	154 ± 65	115 ± 46	215 ± 90	103 ± 34	0.318	0.004	0.068
AST (U/L)	56 ± 28	15 ± 4	50 ± 18	17 ± 2	0.303	<0.001	0.596
ALT (U/L)	77 ± 49	81 ± 45	80 ± 51	98 ± 25	0.799	0.382	0.754
AST:ALT ratio	0.8 ± 0.2	0.2 ± 0.1	0.7 ± 0.2	0.2 ± 0.1	0.522	<0.001	0.600
Fasting glucose (mg/dL)	122 ± 55	106 ± 21	113 ± 34	87 ± 14	0.563	0.328	0.900
Hepatic TG content (%)
Absolute	19 ± 10	14 ± 7	22 ± 13	10 ± 7	0.988	<0.001	0.049
Fractional	100	72 ± 23	100	45 ± 14	0.008	<0.001	0.008

¹ALT, alanine aminotransferase; AST, aspartate aminotransferase; NAFLD, nonalcoholic fatty liver disease; TG, triglyceride.

²Analysis by 2-factor repeated-measures ANOVA unless otherwise indicated.

³Mean ± SD (all such values).

⁴Unpaired t test.

⁵Fisher's exact test.