Table 4.

Associations of single-nucleotide polymorphisms from published genome-wide association studies of coronary artery disease/myocardial infarction with plasma CXCL12 levels in PennCath and PennCAC

SNP	Published risk allele, OR for CAD/MI (P-value)	Linear regression models	PennCath covariate effecta for plasma CXCL12 (P-value)	PennCAC covariate effecta for plasma CXCL12 (P-value)	Meta-analysis Z-score (P-value)b
rs501120	T, 1.33 (10−8)c	Model 1d	0.059 (0.038)	0.067 (0.007)	—
		Model 2e	0.055 (0.041)	0.065 (0.007)	3.43 (6.0 × 10−4)
		Model 3f	0.057 (0.048)	0.063 (0.008)	—
rs1746048	C, 1.17 (10−9)g	Model 1d	0.061 (0.036)	N/A	N/A
		Model 2e	0.060 (0.034)	N/A	N/A
		Model 3f	0.059 (0.044)	N/A	N/A

^aβ and P-value are for additive test based on the risk allele, C for rs1746048 and T for rs501120.

^bOn the basis of the sample size of n = 2939, summary statistics derived from model adjusted for age and gender in both PennCath and PennCAC.

^cData derived from Wellcome Trust Case Control Consortium and German MI Study.^1,2

^dModel 1: unadjusted association.

^eModel 2: adjusted for age, gender, and CAD status in PennCath and adjusted for age and gender in PennCAC.

^fModel 3: further adjusted for type 2 diabetes, hypertension, and tobacco use.

^gData derived from Myocardial Infarction Genetics Consortium Study.³