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Immunostaining of GM1 and GA1 in the mouse brain. The R201C mouse, 3 months old, was given orally a water solution of 1 mM NOEV ad libitum for 1 week, and the fronto-temporal cortex and brainstem were stained as described in Materials and Methods. (A and C) Fronto-temporal cerebral cortex. (B and D) Trigeminal nucleus of brainstem. (A and B) After NOEV treatment. (C and D) Before NOEV treatment. A remarkable decrease of both GM1 and GA1 is observed in the brain after the NOEV treatment.
