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. Author manuscript; available in PMC: 2011 Oct 1.
Published in final edited form as: Nat Struct Mol Biol. 2011 Mar 6;18(4):410–415. doi: 10.1038/nsmb.1999

Figure 3.

Figure 3

MED25 VBD adopts a rare seven-strand β-barrel fold. Cartoon drawing of MED25 VBD accompanied by three structural homologues found using DALI35: Two β-barrel-domains from the KU70-KU80 complex (PDB 1JEQ26) and the SPOC (PDB 1OW125) domain of SPEN. The three homologous structures exhibit a different topology and lack the C-terminal helix present in MED25 VBD. The three MED25 VBD homologues are shown from left to right in decreasing degree of structural homology.