Table 1.
The calpain family
| Calpains | Other names | Gene | Locus (human) | EF-hands | Localization |
|---|---|---|---|---|---|
| Calpain 1 | capn1 | 11q13 | + | ubiquitous | |
| Calpain 2 | capn2 | 1q41 | + | ubiquitous | |
| Calpain 3 | p94 | capn3 | 15q15 | + | muscle, lens, retina |
| Calpain 5 | htra3 | capn5 | 11q14 | − | brain, testis |
| Calpain 6 | CAPNX | capn6 | Xq23 | − | placenta, embryo |
| Calpain 7 | palBH | capn7 | 3p24 | − | ubiquitous |
| Calpain 8 | nCL-2 | capn8 | 1q32-41 | + | stomach |
| Calpain 9 | nCL-4 | capn9 | 1q42-43 | + | digestive tract |
| Calpain 10 | capn10 | 2q37 | − | ubiquitous | |
| Calpain 11 | capn11 | 6p12 | + | testis | |
| Calpain 12 | capn12 | 19q13 | + | hair follicle | |
| Calpain 13 | capn13 | 2p21-22 | + | ubiquitous | |
| Calpain 14 | capn14 | 2p21-22 | − | ? | |
| Calpain 15 | SolH | capn15 | 16p13 | − | ubiquitous |
| Calpain-7-Like | CAPN7L | C6orf103 | 6q24 | − | ? |
| Calpain S1 | Calpain 4 | capns1 | 19q13 | + | ubiquitous |
| Calpain S2 | capns2 | 16q12 | + | NA | |
| Calpastatin | CAST | cast | 5q15 | ubiquitous | |