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. 2003 Dec 15;100(26):15924–15929. doi: 10.1073/pnas.0306981100

Fig. 3.

Fig. 3.

PPARδ agonist increases metabolic rate and attenuates body weight gain and adiposity in HFD-fed C57BL/6J mice. (A) Body weight change. (B) Food intake. (C) Oxygen consumption measurement. (D) Adipose tissue weight. (E) Morphological characterization of BAT (×40 magnification). (F) Electron microscopic analysis of mitochondrial biogenesis and lipid accumulation in skeletal muscle (×2,500 magnification). Asterisks, lipid droplets; arrows, mitochondria. (G) Morphological characterization of liver (×20 magnification). Each symbol or bar represents the mean ± SE of five mice. *, P < 0.05; **, P < 0.01; compared with vehicle-treated control. ORO, Oil red O.