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. Author manuscript; available in PMC: 2011 Apr 14.
Published in final edited form as: Mol Cell Pharmacol. 2010;2(5):191–202.

Figure 1. Schematic representation of the two human estrogen receptors, ERα and ERβ.

Figure 1

Both receptors contain five functional domains (A-E) as other members of the nuclear hormone receptor superfamily and an additional F domain at C terminal. Functional domains include, the DNA-binding domain (DBD), the Ligand-binding domain (LBD), the ligand-independent activation function AF-1, ligand-dependent activation function AF-2. The percentage identity between the two receptors is indicated.