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. Author manuscript; available in PMC: 2011 Apr 14.
Published in final edited form as: Mol Cell Pharmacol. 2010;2(5):191–202.

Figure 4. Differential recruitment of coregulatory complexes to the promoter region of un/hypomethylatedvshypermethylated ER.

Figure 4

ER promoter is un/hypomethylated in ER-positive breast cancer cells with acetylated histones and binding of coactivator complexes. In contrast, ER promoter is hypermethylated in ER-negative breast cancer cells with deacetylated histones and binding of various methyl-binding proteins (MBD1, MBD2 and MeCP2) and DNA methyltransferases (DNMT1 and DNMT3b).