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. Author manuscript; available in PMC: 2011 Oct 1.
Published in final edited form as: Pharmacogenet Genomics. 2010 Oct;20(10):575–585. doi: 10.1097/FPC.0b013e32833b04af

Table 1.

Kinetic analysis of UGTs active against 17-dihydroexemestane

UGT Vmax (pmol/min/μg UGT protein)a KM (μmol/l) Vmax/KM (nl/min/μg UGT protein)a
UGT1A8 0.30 ± 0.06 14 ± 3.9 22 ± 2.1
UGT1A10 12 ± 1.8 124 ± 15 100 ± 7.9
UGT2B17 2.0 ± 0.25 15 ± 2.7 137 ± 17
UGT1A424Pro/48Leu 0.27 ± 0.01 34 ± 3.9 8.1 ± 0.9
UGT1A424Thr/48Leu 0.26 ± 0.04 28 ± 7.8 9.8 ± 1.9
UGT1A424Pro/48Val 0.40 ± 0.03* 36 ± 5.4 12 ± 2.4
a

All kinetic data for different UGT-overexpressing cell homogenates are normalized per μg UGT protein as determined by western blot analysis as described earlier [29,30].

*

P < 0.005, as compared with UGT1A424Pro/48Leu.