Table 2.
Kinetic analysis of 17-dihydroexemestane glucuronidation by individual HLM specimens from individuals stratified by UGT2B17 genotype
| HLM No. | UGT2B17 genotype | Vmax (pmol/min/mg)a | KM (μmol/l) | Vmax/KM (μl/min/mg)a |
|---|---|---|---|---|
| 972 | (*1/*1) | 51.6 | 10.6 | 4.9 |
| 1183 | (*1/*1) | 322 | 7.2 | 45.0 |
| 1392 | (*1/*1) | 393 | 7.1 | 55.0 |
| 2167 | (*1/*1) | 38.9 | 5.1 | 7.6 |
| 2412 | (*1/*1) | 213 | 6.7 | 32.0 |
| mean ± SD | 204 ± 158 | 7.3 ± 2.0 | 28.8 ± 22.3 | |
| 383 | (*2/*2) | 17.0 | 9.3 | 1.8 |
| 416 | (*2/*2) | 5.6 | 17.0 | 0.3 |
| 2174 | (*2/*2) | 13.0 | 12.4 | 1.0 |
| 2175 | (*2/*2) | 2.3 | 13.0 | 0.2 |
| 3873 | (*2/*2) | 8.1 | 11.0 | 0.8 |
| mean ± SD | 9.2 ± 5.9 | 12.6 ± 3.0 | 0.8 ± 0.6 | |
| P valueb | 0.025 | 0.012 | 0.023 |
HLM, human liver microsome.
a
Kinetic data expressed per mg HLM protein.
b
Comparing the UGT2B17 (*1/*1) versus (*2/*2) groups.