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Time-courses of methylation of selected B[a]PDE-damaged duplexes by Dnmt3a-CD under conditions of DNA excess over enzyme. The reaction mixtures contained 2–2.5 μM DNA, 0.69 μM Dnmt3a-CD, and 2 μM [CH3-3H]AdoMet. Designations are as specified for Fig. 3B.
