Table 3.
Effects of two randomisations, their interaction, and their combination, on mean final height and mean maximum height
| Randomisation | Mean/mean difference (SE) | Mean/mean difference (SE) | Difference (95% CI) | P value |
|---|---|---|---|---|
| Randomisation 1 | (Oxandrolone) | (Placebo) | ||
| Final height (cm) | 154.2 (0.8) (n=39) | 149.6 (1.1) (n=43) | 4.6 (1.9 to 7.2) | 0.001 |
| Maximum height (cm) | 153.6 (0.9) (n=43) | 149.3 (1.0) (n=49) | 4.3 (1.6 to 6.9) | 0.002 |
| Randomisation 2 | (Induction at 14 years) | (Induction at 12 years) | ||
| Final height (cm) | 154.0 (1.2) (n=23) | 150.2 (1.4) (n=25) | 3.8 (0.0 to 7.5) | 0.05 |
| Maximum height (cm) | 152.4 (1.4) (n=28) | 150.0 (1.3) (n=28) | 2.4 (−1.5 to 6.2) | 0.2 |
| Interaction of R1 by R2* | (Oxandrolone (14 years−12 years)) | (Placebo (14 years−12 years)) | ||
| Final height (cm) | 0.7 (1.7) (n=21) | 6.2 (2.7) (n=27) | −5.5 (−12.4 to 1.4) | 0.1 |
| Maximum height (cm) | −1.5 (2.5) (n=24) | 4.7 (2.5) (n=32) | −6.2 (−13.5 to 1.2) | 0.1 |
| Combination of R1 and R2† | (Oxandrolone OR 14 years) | (Placebo AND 12 years) | ||
| Final height (cm) | 154.1 (0.9) (n=34) | 147.0 (2.0) (n=14) | 7.1 (3.4 to 10.8) | <0.001 |
| Maximum height (cm) | 153.0 (1.0) (n=39) | 147.2 (1.7) (n=17) | 5.8 (1.9 to 9.7) | 0.004 |
*Summary statistics under oxandrolone and placebo are differences in mean height (SE) between corresponding 14 year and 12 year induction groups.
†Groups: oxandrolone/12 years, oxandrolone/14 years, and placebo/14 years combined; and placebo/12 years.