Table 2.
Quantitative trait associations for MME
| rsID | Trait | Genotypes | Significance | ||
|---|---|---|---|---|---|
| rs3736187 | G/G | A/G | A/A | ||
| Aβ42 | 0±0 (0) | 579±26 (80) | 543±8.5 (579) | NS | |
| Tau | 0±0 (0) | 658±40.5 (80) | 619±13.1 (593) | NS | |
| AAO | 0±0 (0) | 71.1±0.8 (63) | 73.3±0.3 (508) | NS | |
| MMSE | 0±0 (0) | 22.0±0.6 (61) | 21.6±0.2 (490) | NS | |
| rs701109 | C/C | C/T | T/T | ||
| Aβ42 | 532±19.8 (116) | 554±12.3 (298) | 518±11.9 (254) | NS | |
| Tau | 647±31.9 (119) | 613±17.7 (304) | 635±19.5 (261) | NS | |
| AAO | 72.5±0.8 (100) | 72.5±0.5(257) | 73.1±0.5 (234) | NS | |
| MMSE | 21.2±0.6 (96) | 21.5±0.3 (247) | 21.2±0.4 (229) | NS | |
| rs989692 | T/T | C/T | C/C | ||
| Aβ42 | 565±18.3 (149) | 535±10.4 (360) | 534±16.2 (173) | NS | |
| Tau | 637±28.9 (150) | 622±16.1(367) | 627±23.8 (181) | NS | |
| AAO | 73.6±0.6(126) | 73.4±0.4 (307) | 71.5±0.7 (157) | F(2,573) = 3.3, P = 0.036 | |
| MMSE | 21.8±0.5 (113) | 21.5±0.3 (304) | 21.8±0.4 (156) | NS | |
Genotypic means of quantitative traits ± SEM (N) for three markers in MME. Data for Aβ42 and Tau are shown for all available materials (including cases and controls). Data for AAO and MMSE are for AD cases only. P-values < 0.05 are shown estimated using ANOVA and have been adjusted for disease status (AD, control), age, and gender, APOE-e4 status, as well as a sample identifier in statistical analyses (ANOVA). Aβ42 β-amyloid 42, AAO Age-at-onset, MMSE mini-mental state examination, NS not significant. We note that the same models with covariate adjustment indicate strong significance for an effect of APOE on Aβ42 levels (E4 carriers vs. non-carriers; P << 0.0001). The significance of the model for rs989692 and AAO is consistent with statistical noise.