Table 3.

Genotypes distribution of CYP7A1 polymorphisms and their odds ratios for colorectal cancer risk

	Proximal colon									Distal colon + Rectum
	Log additive model			Dominant model			Recessive model			Log additive model			Dominant model			Recessive model
	OR*1	95% CI	p-value	OR*1	95% CI	p-value	OR*1	95% CI	p-value	OR*1	95% CI	p-value	OR*1	95% CI	p-value	OR*1	95% CI	p-value
rs11786580	1.72	1.10-2.71	0.018	1.62	0.99-2.66	0.056	6.88	1.39-34.0	0.018	1.11	0.82-1.51	0.49	1.12	0.81-1.55	0.485	1.15	0.20-6.49	0.874
rs3747809	0.71	0.34-1.46	0.345	0.72	0.34-1.54	0.402	NE*2	-	-	0.92	0.63-1.33	0.65	0.88	0.58-1.33	0.544	1.32	0.32-5.44	0.696
rs2162459	0.82	0.61-1.10	0.188	0.56	0.35-0.89	0.015	1.02	0.66-1.59	0.926	1.03	0.86-1.22	0.755	1.13	0.81-1.56	0.476	0.98	0.76-1.28	0.908
rs3808607(−204A>C)	0.98	0.73-1.32	0.888	0.75	0.48-1.17	0.204	1.30	0.81-2.07	0.276	0.96	0.81-1.15	0.67	0.96	0.73-1.27	0.773	0.94	0.70-1.26	0.679
rs3824260	0.98	0.73-1.31	0.874	0.74	0.47-1.16	0.193	1.30	0.81-2.08	0.274	0.97	0.81-1.15	0.705	0.96	0.72-1.26	0.744	0.96	0.71-1.28	0.769

^*1Adjusted for age as continuous variable, drinking (non, low, moderate, heavy, and unknown), smoking (non, moderate, heavy, unknwon), BMI (<22.5, <25, <27.5, 27.5-, unknown), folate in tertile (T1, T2, T3, and unknown), total energy intake, family history of colorectal cancer, average recreational exercise (none, <0.5 hour/day, 0.5-hour/day) in polytomous logistic regression models.

^*2NE indicates not estimated.