Table 5.

Impact of the TAAGG haplotype stratified by potential confounders

	Controls			Proximal colon						Distal colon + Rectum
	Diplotypes			Log additive model						Log additive model
	Non-TAAGG*1	Heterozygous	Homozygous	Non-TAAGG*1	Heterozygous	Homozygous	OR*2	95% CI	p-value	Non-TAAGG*1	Heterozygous	Homozygous	OR*2	95% CI	p-value
Sex
Male	497	99	3	41	14	2	1.90	1.07-3.36	0.028	186	37	1	0.98	0.66-1.47	0.932
Female	300	61	1	30	8	1	1.63	0.73-3.66	0.233	105	27	1	1.23	0.75-2.03	0.410
Age groups
<60	387	81	3	22	10	1	2.41	1.17-4.96	0.017	162	32	2	0.99	0.65-1.50	0.956
≥60	410	79	1	49	12	2	1.68	0.90-3.11	0.102	129	32	0	1.19	0.76-1.88	0.448
Recreational exercise
No	292	55	2	22	5	2	2.39	1.04-5.51	0.041	124	26	1	1.12	0.69-1.80	0.656
Yes	505	105	2	49	17	1	1.76	1.00-3.09	0.048	167	38	1	1.13	0.76-1.70	0.541
Body mass index*3
<25 kg/m2	586	121	3	53	16	2	1.67	0.97-2.87	0.065	222	46	2	1.03	0.72-1.47	0.863
≥ 25 kg/m2	202	38	1	17	6	1	2.20	0.87-5.55	0.095	68	17	0	1.30	0.69-2.45	0.418
Folate consumption*4
Tertile 1	261	54	0	18	3	3	2.46	1.07-5.64	0.034	119	21	1	0.93	0.55-1.58	0.797
Tertile 2/3	527	99	3	51	19	0	1.72	0.97-3.03	0.062	169	42	1	1.30	0.88-1.92	0.188
Drinking*5
< 23g/day	581	119	3	57	18	1	1.49	0.87-2.54	0.144	201	41	2	1.10	0.76-1.61	0.603
≥ 23g/day	202	40	1	14	4	2	3.02	1.22-7.51	0.017	88	19	0	0.99	0.55-1.79	0.983
Smoking*6
Pack-year < 20	505	101	3	48	17	1	1.72	0.98-3.03	0.059	150	39	2	1.32	0.89-1.96	0.167
Pack-year≥ 20	285	58	1	23	5	2	1.85	0.84-4.06	0.126	137	25	0	0.86	0.52-1.43	0.565
Family history of colorectal cancer in first degree relatives
No	778	150	3	65	20	3	1.84	1.15-2.94	0.010	277	61	2	1.19	087-1.62	0.289
Yes	19	10	1	6	2	0	NE*7	-	-	14	3	0	NE*7	-	-

^*1Non-TAAGG indicates diplotypes not including the TAAGG haplotypes

^*2Adjusted for age as continuous variable, drinking (non, low, moderate, heavy, and unknown), smoking (non, moderate, heavy, unknwon), BMI (<22.5, <25, <27.5, 27.5-, unknown), folate in tertile (T1, T2, T3, and unknown), total energy intake, family history of colorectal cancer, average recreational exercise (none, <0.5 hour/day, 0.5-hour/day) in polytomous logistic regression models. A stratification factor was excluded from the models

^*3Ten controls, one proximal colon cancer case and two distal colorectal/rectal cancer cases were excluded from analysis because of lack of body mass index information

^*4Seventeen controls, two proximal colon cancer cases, and four distal colorectal/rectal cancer cases were excluded from analysis because of lack of folate information.'

^*5Fifteen controls and six distal colorectal/rectal cancer cases were excluded from analysis because of lack of drinking information

^*6Eight controls and four distal colorectal/rectal cancer cases were excluded from analysis because of lack of smoking information.

^*7NE indicates not evaluable due to lack of cases.