Table 1.
Characteristics of study participants *
| Nurses Health Studies † | NECC | |||||
|---|---|---|---|---|---|---|
| Characteristic ‡ | Cases | Controls | P§ | Cases | Controls | P§ |
| N | 233 | 663 | 1120 | 1160 | ||
| Mean (SD) | Mean (SD) | |||||
| Age (yrs) § § | 59.4 (9.9) | 59.2 (10.0) | 51.7 (12.7) | 51.1(12.9) | ||
| BMI (Kg/m2) | 26.0 (5.5) | 25.6 (4.7) | 26.3 (6.3) | 25.7(5.5) | ** | |
| Parity ‖ | 3.0(1.3) | 3.2(1.5) | ** | 2.6 (1.3) | 2.8 (1.5) | ** |
| Duration of OC (mos) † † | 47.8 (41.6) | 53.9 (48.9) | 53.1(54.7) | 60.9 (55.3) | ** | |
| Age at menarche (yrs) | 12.7 (1.5) | 12.5 (1.4) | 12.6 (1.5) | 12.7 (1.6) | ||
| Age at first birth (yrs) ‖ | 25.1(3.8) | 24.9 (3.3) | 24.7 (5.0) | 25.1 (5.0) | ||
| % | % | |||||
| Nulliparous | 11.2 | 7.5 | 32.0 | 18.7 | ** | |
| Breastfeeding (18+ mos) ‖ | 11.8 | 15.3 | 8.7 | 13.6 | ** | |
| Postmenopausal § § | 73.8 | 70.9 | 52.1 | 49.9 | ||
| Current smoker | 11.2 | 10.3 | 22.0 | 19.7 | ||
| History of tubal ligation | 15.5 | 21.4 | ** | 13.8 | 18.2 | ** |
| Hystory of hysterectomy | 19.7 | 16.7 | 8.2 | 8.5 | ||
| Family history of ovarian cancer | 7.3 | 3.3 | ** | 5.0 | 2.9 | ** |
| Family history of breast cancer | 13.3 | 13.7 | 14.2 | 12.0 | ||
| Regular use any NSAIDs ‡ ‡ | 39.1 | 37.3 | 18.4 | 21.8 | ** | |
| CYP2C9 R144C/ I359L ‖ ‖ | 37.0 | 36.1 | 34.4 | 34.6 | ||
| UGT1A6 T181A/R184S ‖ ‖ | 56.5 | 60.0 | 57.6 | 58.1 | ||
| COX-2 765G>C/Ex10+837T>C ‖ ‖ | 59.0 | 56.0 | 54.0 | 56.2 | ||
*
Restricted to Caucasians and to those with genotyping data.
†
Includes epithelial ovarian cancer cases (incident and prevalent cases diagnosed ≤4years of blood collection) and their matched controls
‡
Characteristics ascertained 2-4 years (NHS/NHS-II) and 1 year (NECC) prior to ovarian cancer diagnosis
§
P-values adjusted for matching factors
§ §
Matching factor (only NHS/NHSII matched on menopausal status)
**
P-value<0.05
‖
Among parous participants
† †
Among partipants who ever used oral contraceptives (OC)
‡ ‡
Regular user if 2+ times a week (NHS/NHS-II) or 2+ tablets/week (NECC)
‖ ‖
Any variant allele